1/5/15 • General

Statement by the Corn Refiners Association on the recent University of Utah Study on the Effects of Fructose Consumption on Female Mice

WASHINGTON, DC – “Speculation that a recent rodent study conducted by the University of Utah, in which high fructose corn syrup (HFCS) and sucrose were fed to mice, might have relevance to women’s life expectancy or reproductive health may generate sensationalized headlines, but it lacks scientific merit and mischaracterizes the effect of consuming HFCS.

“Sucrose (table sugar) and HFCS are nutritionally equivalent and comprised of roughly 50 percent fructose and 50 percent glucose. Fructose and glucose form a covalent bond in table sugar as opposed to HFCS. However, this difference is inconsequential. According to the FDA, “Once one eats [sucrose], stomach acid and gut enzymes rapidly break down this chemical bond.”

“Furthermore, the claim that consuming unbound fructose and glucose may uniquely affect female reproductive health is also highly questionable and irresponsible. Human reproduction is regulated by the endocrine system and the overwhelming scientific evidence shows no difference between the effects of high fructose corn syrup and sucrose on the endocrine system in humans.

“Finally, this study was conducted on mice as opposed to human participants. The physiological and psychological differences between humans and rodents are so diverse that you simply cannot compare the two when determining the health impact of any food or ingredient.

“This is why the U.S. Food and Drug Administration (USDA) classifies animal-based studies as having low evidentiary value and has concluded that consuming sugar/HFCS in moderate amounts is safe for humans.”


The Corn Refiners Association (CRA) is the national trade association representing the corn refining industry of the United States. CRA and its predecessors have served this important segment of American agribusiness since 1913. Corn refiners manufacture sweeteners, ethanol, starch, bioproducts, corn oil and feed products from corn components such as starch, oil, protein and fiber.